Development of an Interleukin-11 Signalling Antagonist

The structure of the IL-11 signalling complex provides insight into receptor variants associated with craniosynostosis

DD Sentosa, RD Metcalfe, NA Sims, TL Putoczki, MDW Griffin

2025-02-01

Interleukin 11 (IL-11), a member of the IL-6 family of cytokines, has roles in haematopoiesis, inflammation, bone metabolism, and ..

Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant

RD Metcalfe, E Hanssen, KY Fung, K Aizel, CC Kosasih, CO Zlatic, L Doughty, CJ Morton, AP Leis, MW Parker, PR Gooley, TL Putoczki, MDW Griffin

2023-12-01

Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers...

Emerging roles for IL-11 in inflammatory diseases

KY Fung, C Louis, RD Metcalfe, CC Kosasih, IP Wicks, MDW Griffin, TL Putoczki

2022-01-01

Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignan..

Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome

YH Chen, DB Zastrow, RD Metcalfe, L Gartner, F Krause, CJ Morton, S Marwaha, L Fresard, Y Huang, C Zhao, C McCormack, D Bick, EA Worthey, CM Eng, J Gold, null Undiagnosed Diseases Network, SB Montgomery, PG Fisher, EA Ashley, MT Wheeler

2021-08-01

Background: Biallelic variants in IL6ST, encoding GP130, cause a recessive form of hyper-IgE syndrome (HIES) characterized by high..

Type 2 innate lymphoid cells protect against colorectal cancer progression and predict improved patient survival

Q Huang, N Jacquelot, A Preaudet, S Hediyeh‐zadeh, F Souza‐fonseca‐guimaraes, ANJ McKenzie, PM Hansbro, MJ Davis, LA Mielke, TL Putoczki, GT Belz

2021-02-01

Chronic inflammation of the gastrointestinal (GI) tract contributes to colorectal cancer (CRC) progression. While the role of adap..

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11

RD Metcalfe, TL Putoczki, MDW Griffin

2020-07-16

Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the di..

The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement

RD Metcalfe, K Aizel, CO Zlatic, PM Nguyen, CJ Morton, DSS Lio, HC Cheng, RCJ Dobson, MW Parker, PR Gooley, TL Putoczki, MDW Griffin

2020-06-12

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-..

Emerging roles for Interleukin-11 in disease

PM Nguyen, SM Abdirahman, TL Putoczki

2019-01-01

Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the abil..